Stereochemistry of Dihydropyrimidinones Derivatives Synthesized by Brick Dust Catalytic Reaction

A number of catalytic synthetic reactions have been reported which play the important role in stereochemistry compounds. The key to success this protocol was generation stereogenic centers 1, 4-Dihydropyrimidinones (DHPMs) and influence catalysts on their configuration. Waste brick dust found be an effective catalyst, generating chiral DHPMs derivatives using aryl aldehyde, urea, ethyl acetoacetate. This work mainly focuses brick-dust catalyzed derivatives. Discovery catalyst associated with several benefits such as rapid clean reaction, simple, ease work-up.